Influência dos hormônios esteroides sexuais femininos na resistência insulínica em cadelas - revisão bibliográfica

Abstract

Insulin resistance is a term that refers to the ineffective action of insulin in tissues, being developed by several factors, from infectious and nutritional diseases to the hormonal influence by endocrinopathies, use of diabetogenic drugs and physiological hormonal periods in female dogs. This review aims to describe the influence of female sex steroid hormones on the triggering of insulin resistance in non-castrated female dogs. It is observed that the mechanism of action of insulin is compromised by the action of progesterone and estradiol in the body in addition to other hyperglycemic hormones that together with genetic, environmental and autoimmune factors, can trigger transient or gestational diabetes in female dogs. It is concluded that diabetes mellitus in whole canine patients intensifies the definition of endocrinopathy as a multifactorial disorder, where there are few studies involving transient or gestational diabetes mellitus, but its risk is mentioned in the literature due to the possibility of a permanent picture in some cases. and for being responsible for conveying the importance of castration in the control of diabetic bitches and in the prevention of those at risk.