Fibras de poli (caprolactona) obtidas por eletrofiação contendo ácido gálico

Abstract

Poly (ε-caprolactone) (PCL) is a polymer of the class of aliphatic polyesters very important for medical application. Gallic acid (GA) is found in many types of plants. This substance is a natural polyphenol, and its derivatives are compounds of great interest in the pharmaceutical industry. The applications of PCL fibers obtained by electrospinning have been frequently reported in the literature. In the present work, PCL membranes incorporated with GA were produced. The membranes received morphological characterization by scanning electron microscopy (SEM). Statistical study of the measurements of the fiber diameters that were obtained manually in the ImageJ image analyzer software (free version). The influence of GA concentrations (0.4, 0.7, 1, 5 and 10% wt) on the final characteristics of the fibers produced was evaluated. For AG concentrations of 0.4; 0.7; 1 and 5 wt% it was possible to produce PCL / AG membranes. It was not possible to produce membranes with a concentration of 10wt% due to AG precipitation in the PCL solution. The concentration of 0.4 wt% and 0.7 wt% GA is most suitable for incorporation of the drug into PCL fibers. PCL with AG membranes successfully developed are promising for medical application.